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Crucially, a strong inverse correlation was observed between the ability of the curcumin derivatives to displace a fluorescent probe from HaSCP-2s sterol binding site and their capacity to inhibit Sf9 insect cell growth in culture

Note, however, that pyruvate is a potent negative effector on all PDKs, with the result that when pyruvate levels rise, active PDH will be favored even with high levels of NADH and acetyl-CoA